Inability of passively acquired antibody to protect lambs against experimental pasteurellosis

Inability of passively acquired antibody to protect lambs against experimental pasteurellosis.

An experimental model of pneumonic pasteurellosis in sheep was used to investigate the role of serum antibody in resistance to this disease. Lambs which had been vaccinated with a sodium salicylate extract of Pasteurella haemolytica type A1 were protected against challenge with PI3 virus followed by P. haemolytica type A1 7 days later. The majority of untreated lambs and lambs which had receive...

A monoclonal antibody against a Pasteurella multocida outer membrane protein protects rabbits and mice against pasteurellosis.

Monoclonal antibodies (MAbs) directed against the 37.5-kDa outer membrane protein were produced by fusing myeloma cells with spleen cells obtained from mice immunized with a pathogenic strain of Pasteurella multocida isolated from a rabbit. Desirable MAbs were selected by enzyme-linked immunosorbent assay, whole-cell radioimmunoprecipitation (WC-RIP), and Western blot (immunoblot) analysis. WC-...

Antibody response against hydatid fluid, protoscolex and whole body of Echinococcus granulosus antigens in lambs

In this study, the immunogenicity of three types of antigens (hydatid fluid, protoscolices and whole body of E. granulosus) was investigated in lambs by ELISA. Sixteen 4–6-month-old lambs of mixed sexes were divided into 4 groups of 4 lambs (three immunized and one control group). Twelve lambs as immunized groups received 2 mg of hydatid fluid, protoscolices and whole body of E. granulosus ant...

Active immunisation of lambs with a monoclonal antibody against clenbuterol

An experiment was undertaken with 50 Texel 3 Suffolk-Cheviot lambs (5468.8 days of age) to investigate the effects of active immunisation with a murine monoclonal antibody against clenbuterol on growth and carcass characteristics. Animals on treatments 1 and 2 each received 0.1 mg of clenbuterol antibody while animals on treatments 3 and 4 received 0.1 mg of antibody encapsulated within a synth...

Attempt to protect rabbits against experimental syphilis by passive immunization.